Research

Links to current research studies:

Investigation of the Disease Progression of Pediatric Patients with Incidental Chiari I Malformation

Kerri Thorn, PA-C, Children’s National Medical Center, Washington, DC

The Genetics of Chiari Type I Malformation (CMI) with or without Syringomyelia

Dr. Allison Ashley-Koch, Center for Human Genetics, Duke University Medical School, Durham, North Carolina

Outcomes in Patients Undergoing Surgical Intervention for Chiari Type I Malformation with Syringomyelia

Bermans J. Iskandar, MD, University of Wisconsin at Madison, Tim M. George, MD, University of Texas at Austin

Magnetic Resonance Imaging (MRI) and Quantitative MR Cerebral Spinal Fluid (CSF) Flow Studies in Craniovertebral Junction Anomalies

Pediatric Neurosurgery Research at Children’s Memorial Medical Center and Children’s Research Medical Center, Chicago

Chandra Shekhar Myanil, M.D., Northwestern University Feinberg School of Medicine, Shunsuke Ichi, M.D., University of Tokyo

Also from Dr. Myanil, this quote:

“Lack of proper neural tube closure as in Spina bifida is the root cause of all the developmental abnormalities such as Hydrocephalus and Chiari II malformation.   With open neural tube the cerebrospinal fluid leaks, resulting in the brain to descend into first cervical spine.    Thus essentially all Spina Bifida patients have the intermediate form (Chiari Type II or Arnold-Chiari malformation).  Many changes of the brain are associated with this abnormality such as Hydrocephalus.   Thus proper closure of the neural tube during development is absolutely necessary if we want to eliminate Chiari malformation and Hydrocephalus from human population. Our goal is to find cure for Spina Bifida so that it can be fixed in the uterus itself once it is diagnosed, only then can we can say that we have cured Chiari and other related abnormalities such as Hydrocephalus.  We know more than what we knew yesterday, which is a very promising step in the right direction towards in utero treatment of Spina Bifida and Chiari and Hydrocephalus.”  Chandra Shekhar K. Mayanil. , PhD. Children’s Memorial Research Center @ Children’s Memorial Hospital, Chicago, IL    2010